Medical devices having antimicrobial coatings thereon

Details Medical devices having antimicrobial coatings thereon Medical devices having antimicrobial coatings thereon

A - Human Necessities

61

L

A61L 27/30 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/10 (2006.01) A61L 29/16 (2006.01) A61L 31/08 (2006.01) A61L 31/10 (2006.01) G02B 1/04 (2006.01)

Patent

CA 2510025

The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.

La présente invention concerne un dispositif médical, de préférence une lentille de contact, présentant un matériau noyau et un revêtement LbL à teneur en métal antimicrobien non relié par covalence au dispositif médical et pouvant conférer audit dispositif médical un plus grand caractère hydrophile. Ce revêtement à teneur en métal antimicrobien déposé sur la lentille de contact présente une efficacité antimicrobienne élevée contre les micro-organismes parmi lesquels les bactéries Gram-positives et Gram-négatives, ainsi qu'une toxicité faible; les propriétés générales souhaitées, telles que la perméabilité à l'oxygène et la perméabilité ionique du matériau de la lentille, étant conservées. De telles lentilles de contact sont utilisées en tant que lentilles de contact à port prolongé. En outre, cette invention concerne un procédé permettant de fabriquer un dispositif médical, de préférence une lentille de contact, recouvert d'un revêtement LbL à teneur en métal antimicrobien.

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