A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01)
Patent
CA 2685132
Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2- 2), stxAB, and msbB2 genes. Thus, the vaccine strain will have three or more deletions in the identified genes, will be safer, and will reduce or eliminate symptoms of fever and diarrhea in humans. The following specific vaccine strains have been constructed: WRSS3 (.DELTA.senA, .DELTA.senB, .DELTA.virG, .DELTA.msbB2), WRSf2G15 (.DELTA.virG, .DELTA.setAB, .DELTA.senA, .DELTA.senB, .DELTA.msbB2), and WRSd5 (.DELTA.virG, .DELTA. stxAB, .DELTA.senA, .DELTA.senB, .DELTA.msbB2).
La présente invention concerne des souches de vaccin anti-shigella dont la principale caractéristique d'atténuation se traduit par la délétion du gène virG(icsa), ainsi que par au moins deux délétions supplémentaires dans les gènes setAB(shET1), senA(shET2), senB(shET2- 2), stxAB et msbB2. Ainsi, la souche de vaccin possède au moins trois délétions dans les gènes identifiés, est plus sûre et réduit ou élimine les symptômes de la fièvre et la diarrhée chez l'homme. Les souches particulières de vaccin suivantes ont été obtenues : WRSS3 (.DELTA.senA, .DELTA.senB, .DELTA.virG, .DELTA.msbB2), WRSf2G15 (.DELTA.virG, .DELTA.setAB, .DELTA.senA, .DELTA.senB, .DELTA.msbB2), et WRSd5 (.DELTA.virG, .DELTA. stxAB, .DELTA.senA, .DELTA.senB, .DELTA.msbB2).
Barnoy Shoshana
Ranallo Ryan T.
Venkatesan Malabi M.
Smart & Biggar
The United States Of America As Represented By The Secretary Of Walter Reed Army Institute Of Research
LandOfFree
Combinations of gene deletions for live attenuated shigella... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combinations of gene deletions for live attenuated shigella..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinations of gene deletions for live attenuated shigella... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1549729