Pyridopyrimidinone inhibitors of pim 1 and/or pim-3

Details Pyridopyrimidinone inhibitors of pim 1 and/or pim-3 Pyridopyrimidinone inhibitors of pim 1 and/or pim-3

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/196 (2006.01) A61K 31/381 (2006.01) A61K 31/41 (2006.01) C07C 233/63 (2006.01) C07D 257/04 (2006.01) C07D 307/68 (2006.01) C07D 307/93 (2006.01) C07D 333/38 (2006.01) C07D 333/70 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2623759

Compounds of formula (I), useful for inhibiting PIM-I and/or PIM-3: and pharmaceutically acceptable salts thereof, wherein Y, Z, R1, R3, Q, X and R4 are as defined above. Pharmaceutical compositions and methods of treating diseases and conditions, such as cancer, are also disclosed.

L'invention concerne des composés représentés par la formule I qui inhibent PIM-1 et/ou PIM-3, et des sels pharmaceutiquement acceptables de ces composés, Y, Z, R1, R3, Q, X et R4 étant définis dans le descriptif. Des compositions pharmaceutiques et des méthodes de traitement de maladies et d'états pathologiques tels que le cancer sont également décrites.

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