Quinoline - substituted chromans and related compounds as...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/12 (2006.01) A61K 31/47 (2006.01) C07D 215/18 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2077382

166/GL62 18487 TITLE OF THE INVENTION QUINOLINE-SUBSTITUTED CHROMANS AND RELATED COMPOUNDS AS LEUKOTRIENE ANTAGONISTS ABSTRACT OF THE DISCLOSURE Compounds having the formula I: Image (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

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