A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2719055
The present invention relates to compositions and methods for decreasing an immune response in an animal com-prising administering to said animal an agent that binds a bioactive lipid and reduces the effective concentration of said bioactive lipid. Also provided are methods for treating diseases or conditions, including autoimmune disorders, which are characterized by an aberrant, excessive or undesired immune response. The methods of the invention utilize agents that bind bioactive lipids and are capable of decreasing the effective concentration of the bioactive lipid. In some embodiments, the agent is a monoclonal antibody that is reactive against sphingosine-1-phosphate (SIP) or lysophosphatidic acid (LPA).
La présente invention concerne des compositions et des procédés permettant de réduire une réponse immunitaire chez un animal comprenant l'administration au dit animal d'un agent qui se lie à un lipide bioactif et réduit la concentration effective dudit lipide bioactif. L'invention concerne également des procédés de traitement de maladies ou de conditions pathologiques, comprenant des troubles auto-immuns, qui sont caractérisés par une réponse immunitaire aberrante, excessive ou indésirable. Les procédés selon l'invention utilisent des agents qui se lient à des lipides bioactifs et sont capables de réduire la concentration effective du lipide bioactif. Selon certains modes de réalisation, l'agent est un anticorps monoclonal qui est réactif contre la sphingosine-1-phosphate (SlP) ou l'acide lysophosphatidique (LPA).
Lpath Inc.
Smart & Biggar
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