Cytotoxicity mediation of cells evidencing surface...

Details Cytotoxicity mediation of cells evidencing surface... Cytotoxicity mediation of cells evidencing surface...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2560859

The use of a cancerous disease modifying antibody (CDMAB) H460-16-2 for treating a tumor in humans and methods of isolating and identifying cancerous cells which express a CD44 antigenic moiety. The monoclonal antibody H460-16-2 (ATTC accession number PTA-4621), which binds a CD44 antigenic moiety, is cytotoxic to cancer cells, wherein cytotoxicity is mediated via antibody dependent cell mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). The monoclonal antibody H460-16-2 is useful for delaying the disease progression of a human tumor.

L'invention concerne l'utilisation d'un anticorps de modification d'une maladie cancéreuse (CDMAB) H460-16-2 pour traiter une tumeur chez des humains. L'invention concerne également des méthodes d'isolement et d'identification de cellules cancéreuses exprimant une fraction antigénique CD44. L'anticorps monoclonal H460-16-2 (numéro d'enregistrement ATTC PTA-4621), qui se lie à une fraction antigénique CD44, est cytotoxique pour des cellules cancéreuses, la cytotoxicité étant médiée par une cytotoxicité cellulaire dépendant des anticorps (ADCC) et par une cytotoxicité dépendant du complément (CDC). L'anticorps monoclonal H460-16-2 est utile pour retarder la progression de la maladie d'une tumeur humaine.

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