C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/26 (2006.01) A61K 31/4418 (2006.01) A61K 31/4436 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) C07D 213/55 (2006.01) C07D 213/56 (2006.01) C07D 239/26 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2519677
Biaryl substituted pyridine, pyrimidine and pyrazine compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone , or in combination with one or more other therapeutically active compounds.
L'invention concerne des composés de pyridine, de pyrimidine et de pyrazine à substitution biaryle et des bloqueurs des canaux sodiques utiles pour le traitement de la douleur. Les compositions pharmaceutiques selon l'invention comprennent une quantité efficace desdits composés, seuls ou associés à un ou plusieurs composés thérapeutiquement actifs et un support pharmaceutiquement acceptable. Les méthodes de traitement d'états pathologiques associés à, ou entraînés par, l'activité des canaux sodiques, comprenant, par exemple, la douleur aiguë, la douleur chronique, la douleur viscérale, la douleur inflammatoire, la douleur neuropathique, l'épilepsie, le syndrome du côlon irritable, la dépression, l'anxiété, la sclérose en plaques et les troubles bipolaires, consistent à administrer une quantité efficace desdits composés, seuls ou associés à un ou plusieurs autres composés thérapeutiquement actifs.
Chakravarty Prasun K.
Fisher Michael H.
Liang Jun
Parsons William H.
Zhou Bishan
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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