Hydantoin derivatives useful as metalloproteinase inhibitors

Details Hydantoin derivatives useful as metalloproteinase inhibitors Hydantoin derivatives useful as metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4166 (2006.01) A61K 31/445 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2589525

Formula (I) wherein R1 is a (2-4C)alkyl and is substituted by two or more fluorine groups and R2 is methyl or ethyl, or a pharmaceutically acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by metalloproteinase enzymes.

La présente invention décrit des composés de Formule (I) selon laquelle R1 représente un groupement alkyle en C2-C4 substitué par deux atomes de fluor ou plus, et R2 représente un groupement méthyle ou éthyle, ainsi que des sels de qualité pharmaceutique desdits composés. La présente invention décrit également des procédés de synthèse desdits composés, des préparations pharmaceutiques contenant lesdits composés et leur emploi dans le traitement de maladies ou d'états pathologiques dus à des enzymes métalloprotéases.

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