Quinolone carboxylic acid derivatives in crystalline hydrate...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01)

Patent

CA 2128601

1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3- methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid dihydrate having the following formula: (see formula I) The crystal of this dihydrate exhibits excellent stability over the other crystal forms under various pharmaceutical formulation conditions such as moisture absorption and blending in solvents and, hence, it is a most advantageous crystal form in the manufacture of pharmaceuticals.

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