Medicament for topical application

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/57 (2006.01) A61K 38/36 (2006.01) A61K 38/45 (2006.01) A61K 38/48 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2372929

The invention relates to a medicament for topical application for the purpose of stopping bleedings and/or closing wounds and/or promoting wound healing, which as active substances - produced conventionally of allogenic plasma or tissue or recombinantly - contains fibrinogen or fibrin, thrombin and one or several transglutaminase(s), wherein the medicament, as a further active substance, contains one or several protease inhibitor(s) selected from the group consisting of serpins that do not have inhibiting effects on collagenases and elastases, all of the active substances being of allogenic origin and having been subjected to a process for virus depletion and/or virus inactivation, with the proviso that the virus inactivation of the one or several protease inhibitor(s) has not been carried out in the presence of the other active substances.

L'invention concerne un médicament pour application locale, servant à l'hémostase et/ou la fermeture de plaies et/ou à la stimulation de la cicatrisation. Ce médicament présente comme principes actifs, du fibrinogène ou de la fibrine, de la thrombine et une ou plusieurs transglutaminases, lesdits principes actifs étant produits de manière classique à partir de plasma ou de tissu allogénique ou par génie génétique. Ce médicament contient comme autre principe actif un ou plusieurs inhibiteurs de protéase sélectionnés dans le groupe des serpines ne possédant aucun effet inhibiteur sur les collagénases ni sur les élastases, tous ces principes actifs d'origine allogénique étant soumis à un procédé d'administration de virus et/ou d'inactivation de virus, à condition que l'inactivation de virus d'un ou de plusieurs inhibiteurs de protéase ne soit pas effectuée en présence des autres principes actifs.

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