A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A01K 67/00 (2006.01) C07K 14/71 (2006.01) C12N 15/00 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/00 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2305045
The present invention provides a non-human transgenic animal whose cells express a foreign DNA sequence that encodes a functional vascular endothelial cell receptor domain, but do not express a substantially homologous native DNA sequence. This invention also provides methods of using these transgenic animals for identifying therapeutic and other reagents that affect angiogenesis. Additionally provided are methods of using transgenic animals whose cells contain any donor genes as models for testing various reagents.
La présente invention concerne un animal transgénique non-humain dont les cellules expriment une séquence ADN étrangère codant un domaine fonctionnel du récepteur des cellules endothéliales vasculaires, sans toutefois exprimer de séquence d'ADN natif sensiblement homologue. L'invention concerne également des procédés permettant d'utiliser ces animaux transgéniques pour identifier des agents thérapeutiques et autres réactifs affectant l'angiogenèse. L'invention concerne en outre des procédés permettant l'utilisation d'animaux transgéniques dont les cellules contiennent des gènes donneurs servant de modèle pour le test de divers réactifs.
Bohlen Peter
Pytowski Bronislaw
Sato Thomas
Witte Larry
Beth Israel Hospital
Gowling Lafleur Henderson Llp
Imclone Systems Incorporated
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