Polyamide-oligonucleotide derivatives, their preparation and...

Details Polyamide-oligonucleotide derivatives, their preparation and... Polyamide-oligonucleotide derivatives, their preparation and...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 31/785 (2006.01) A61K 47/48 (2006.01) C07C 237/00 (2006.01) C07K 14/00 (2006.01) C08G 69/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2144475

Polyamide-oligonucleotide derivatives, their preparation and use Polyamide-oligonucleotide derivatives of the formula F[(DNA-Li)q(PNA-Li)r(DNA-Li)s(PNA)t]x F' wherein q, r, s, t are, independently of one another, zero or 1, where the total of two or more adjacent q, r, s and t >= 2; x is 1 to 20; DNA is a nucleic acid such as DNA or RNA or a known derivative thereof; Li is a covalent linkage between DNA and PNA, where the covalent linkage comprises a bond or an organic radical with at least one atom from the series consisting of C, N, O or S; PNA is a polyamide structure which contains at least one nucleotide base which is different from thymine; and F and F' are end groups and/or are linked together by a covalent bond, and the physiologically tolerated salts thereof, a process for their preparation and their use as pharmaceutical, as gene probe and as primer, are described.

Divulgation de dérivés de polyamide-oligonucléotide, de leur préparation et de leur utilisation. Ces dérivés ont la formule F¬(ADN-Li)q(APN-Li)r(ADN-Li)s(APN)t|x F' dans laquelle : q, r, s et t sont, indépendamment l'un de l'autre, égaux à 0 ou 1, le total de deux ou plus de deux q, r, s et t contigus est .supoueg. à 2, x a une valeur de 1 à 20, ADN est un acide nucléique tel qu'un ADN ou un ARN ou un de leurs dérivés connus, Li est un lien covalent entre l'ADN et l'ANP comprenant une liaison ou un radical organique avec au moins un atome de la série composée de C, N, O ou S, APN est une structure de polyamide contenant au moins une base nucléotidique différente de la thymine, F et F' sont des groupes terminaux et/ou sont liés de manière covalente. Divulgation aussi de sels de ces dérivés tolérés physiologiquement et d'un procédé pour leur fabrication et leur utilisation comme produit pharmaceutique, sonde génique ou amorce.

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