Novel polypeptide

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61P 25/08 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) A61P 37/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2352347

Object: to provide diagnostics, preventives and remedies for diseases in association with JNK3 cascade. Means for solution: a novel polypeptide JSAP capable of binding to JNK3; a process for producing this polypeptide; a DNA encoding this polypeptide; a recombinant vector obtained by integrating this DNA; a transformant carrying this recombinant vector; an antibody recognizing the above polypeptide; a method for quantitating the above polypeptide and an immunological staining method with the use of the above antibody; a screening method with the use of the polypeptide; and diagnostics, preventives and remedies for diseases in association with JNK3 cascade with the use of the polypeptide, DNA or antibody as described above.

L'objet de cette invention est de fournir des diagnostics, des traitements préventifs et des traitements curatifs pour les maladies associées à la cascade de la kinase JNK3. L'invention concerne un nouveau polypeptide JSAP capable de se lier à JNK3, un procédé permettant de produire ce polypeptide, l'ADN codant pour ce polypeptide, un vecteur recombinant obtenu par intégration de cet ADN, un transformant porteur de ce vecteur recombinant, un anticorps capable de reconnaître le polypeptide, un procédé permettant de quantifier le polypeptide et un procédé immunologique de coloration pouvant être utilisé avec l'anticorps ci-dessus, ainsi qu'un procédé de criblage comprenant l'utilisation du polypeptide et des diagnostics, traitements préventifs et traitements curatifs pour des maladies associés à la cascade de JNK3, et comprenant l'utilisation du polypeptide, de l'ADN ou de l'anticorps décrits.

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