C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) C12N 15/113 (2010.01) C40B 30/04 (2006.01) C40B 30/06 (2006.01)
Patent
CA 2724454
The invention features methods for identifying compounds that inhibit binding between iron response elements (IREs) and iron response proteins (IRPs). These compounds are potentially useful for treating or preventing diseases, in particular cancer, but also including anemia, neurodegenerative diseases, inflammation and iron overload. The methods are based on contacting a candidate compound in an in vitro system and monitoring the binding of an IRE to an IRP. In addition, the invention features methods of treating or preventing a proliferative disease, such as cancer, using the compounds of the invention.
L'invention propose des procédés d'identification de composés qui empêchent la liaison entre les éléments de réponse au fer (IRE) et les protéines de réponse au fer (IRP). Ces composés sont potentiellement utiles pour traiter ou prévenir des maladies, en particulier le cancer mais également l'anémie, les maladies neurodégénératives, l'inflammation et la surcharge en fer. Les procédés se fondent sur la mise en contact d'un composé candidat dans un système in vitro et la surveillance de la liaison d'un IRE à une IRP. De plus, l'invention comprend des procédés de traitement ou de prévention d'une maladie proliférative telle que le cancer au moyen des composés de l'invention.
Giordano Anthony
Mhashilkar Abner
Gowling Lafleur Henderson Llp
Toucan Capital Corporation
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