N-acetylglucosaminyltransferase vb coding sequence,...

Details N-acetylglucosaminyltransferase vb coding sequence,... N-acetylglucosaminyltransferase vb coding sequence,...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2483436

A previously unknown mammalian UDP-N-acetylglucosamine: .alpha.-6-D mannoside .beta.-1, 6-N-acetylglucosaminyl-transferase (termed GlcNAc T-Vb herein) coding sequence, protein, recombinant host cells and antibodies which specifically bind GlcNAc T-Vb are described. GlcNAc T-Vb is encoded on human chromosome (17), whereas the prior GlcNAc T-V is encoded on human chromosome (2).

L'invention concerne une UDP-N-acétylglucosamine mammalienne inconnue jusqu'ici, la séquence de codage de ?-6-D mannoside ?-1, 6-N-acétylglucosaminyl-transférase (ci-après dénommée GlcNAc T-Vb). Elle concerne également une protéine, des cellules hôtes recombinantes et des anticorps qui se lient de manière spécifique à GlcNAc T-Vb. GlcNAc T-Vb est codée sur le chromosome humain (17), tandis que la GlcNAc T-V antérieure est codée sur le chromosome humain (2).

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