C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 281/02 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) A61K 31/66 (2006.01) A61K 38/05 (2006.01) C07C 243/14 (2006.01) C07C 243/18 (2006.01) C07C 255/60 (2006.01) C07C 271/22 (2006.01) C07C 281/04 (2006.01) C07C 311/05 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 215/48 (2006.01) C07D 257/04 (2006.01) C07D 295/205 (2006.01) C07D 295/215 (2006.01) C07D 307/12 (2006.01) C07D 307/16 (2006.01) C07K 5/06 (2006.01)
Patent
CA 2072785
The invention relates to compounds of formula (see formula I) wherein R1 and R9 are each independently of the other hydrogen; aryl; unsubstituted or substituted alkyl, alkenyl or alkynyl; heterocyclyl; sulfo; sulfonyl substituted by unsubstituted or substituted alkyl, aryl, heterocyclyl, alkoxy, which is unsubstituted or substituted, or by aryloxy; sulfamoyl that is unsubstituted or substituted at the nitrogen atom; or phosphoryl substituted by one or two radicals, which may be identical or different, selected from unsubstituted or substituted alkyl, from unsubstituted or substituted cycloalkyl, from aryl, from hydroxy, from unsubstituted or substituted alkoxy, from cycloalkoxy and from aryloxy; with the proviso that not more than one of the radicals R1 and R9 is hydrogen; and R2 and R8 are each independently of the other hydrogen or one of the radicals mentioned above for R1 and R9; or the pairs of substituents R1 and R2, and R8 and R9, each independently of the other, may form together with the nitrogen atom to which they are bonded certain heterocyclic rings; R3 and R4 are each independently of the other hydrogen; unsubstituted or substituted alkyl or cycloalkyl; aryl; heterocyclyl; or unsubstituted or substituted alkenyl; or R3 and R4 together form unsubstituted or substituted alkylene, alkylidene or benzo- fused alkylene; R5 is hydroxy; R6 is hydrogen; or R5 and R6 together are oxo; and R7 is unsubstituted or substituted alkyl or cycloalkyl; aryl; heterocyclyl; or unsubstituted or substituted alkenyl; and salts of the mentioned compounds where salt-forming groups are present, and to processes for the preparation thereof, to pharmaceutical compositions, to the use thereof as medicaments or for the preparation of pharmaceutical compositions, and to novel intermediates for the preparation of those compounds.
Bold Guido
Faessler Alexander
Lang Marc
Schneider Peter
Ag Ciba-Geigy
Fetherstonhaugh & Co.
Novartis Ag
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