Nucleic acids, proteins, and antibodies

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2393616

The present invention relates to novel testes related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "testicular antigens", and the use of such testicular antigens for detecting disorders of the testes, particularly the presence of testicular cancer and testicular cancer metastases. More specifically, isolated testicular associated nucleic acid molecules are provided encoding novel testes associated polypeptides. Novel testicular polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human testes associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the testes, including testicular cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

La présente invention concerne de nouveaux polynucléotides liés aux testicules, et les polypeptides codés par ces polynucléotides connus ici sous la dénomination collective de "antigènes testiculaires", et l'utilisation d'antigènes testiculaires de ce type pour détecter des troubles liés aux testicules, en particulier la présence du cancer des testicules et de métastases de cancer des testicules. Plus spécifiquement, l'invention concerne des molécules d'acide nucléique isolées associées aux testicules, codant pour de nouveaux polypeptides associés aux testicules. Cette invention concerne également des polypeptides et anticorps testiculaires qui se lient à ces polypeptides ; des vecteurs, des cellules hôtes, des procédés de recombinaison et de synthèse permettant de produire des polynucléotides et/ou polypeptides humains associés aux testicules ; des procédés diagnostiques et thérapeutiques utiles pour le diagnostic, le traitement, la prévention et/ou la prévision de troubles liés aux testicules, y compris le cancer des testicules, et des procédés de traitement de troubles de ce type ; des procédés de criblage permettant d'identifier des agonistes et des antagonistes de polynucléotides et polypeptides de l'invention ; des procédés et/ou des compositions permettant d'inhiber la production et la fonctionnalité de polypeptides de la présente invention.

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