A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7016 (2006.01) A23L 1/29 (2006.01) A23L 1/30 (2006.01) A23L 1/305 (2006.01) A61K 31/685 (2006.01) A61K 38/00 (2006.01) A61P 3/04 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2573261
Attention is focused on a nutritional composition known as having an effect of controlling blood glucose level. This food is administered to rats over a long time and the expression of genes relating to the lipid metabolism in the liver and fat tissues of the animals is analyzed by the real time PCR method. As a result, it is observed that the expression of PPAR.alpha. gene is promoted by the above-described food and, in its turn, the expression of fatty acid metabolism-related genes (i.e., PPAR.alpha. target genes) is promoted while the expression of fatty acid synthases is regulated. Moreover, it is confirmed that the above food exerts an effect of promoting the expression of PPAR.gamma. and adiponectin. Thus, it is found out that this food has effects of enhancing the production of PPAR and PPAR-associated factors.
On attire l'attention sur une composition nutritive connue pour avoir un effet de régulation du niveau de glucose dans le sang. On administre cet aliment à des rats sur une longue durée et on analyse l'expression de gènes concernant le métabolisme des lipides dans le foie et les tissus adipeux des animaux par le procédé d'ACP en temps réel. En conséquence, on observe que l'expression du gène de PPAR.alpha. est favorisée par l'aliment décrit ci-dessus et que, à son tour, l'expression de gènes liés au métabolisme des acides gras (c'est-à-dire de gènes de PPAR.alpha. cibles) est favorisée alors que l'expression d'acides gras synthétases est régulée. De plus, on confirme que l'aliment ci-dessus exerce un effet promoteur de l'expression de PPAR.gamma. et d'adiponectine. Ainsi, on a trouvé que cet aliment a des effets d'accroissement de la production de PPAR et de facteurs associés aux PPAR.
Arai Hidekazu
Sasaki Hajime
Takeda Eiji
Meiji Co. Ltd.
Meiji Dairies Corporation
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The University Of Tokushima
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