C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/425 (2006.01) A61P 3/00 (2006.01) A61P 9/08 (2006.01) C07D 211/00 (2006.01) C07D 277/00 (2006.01)
Patent
CA 2525501
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans. Formula (I).
Activateurs de PPAR-.alpha., compositions pharmaceutiques contenant de tels composés et utilisation de ces derniers pour augmenter certains taux de lipides plasmatiques, y compris le cholestérol à lipoprotéines de haute densité (HDL), et pour abaisser d'autres taux de lipides plasmatiques, tels que le cholestérol à lipoprotéines de basse densité (LDL), et traiter ainsi des maladies exacerbées par de faibles taux de cholestérol HDL et/ou de forts taux de cholestérol LDL et de triglycérides, telles que l'athérosclérose et les maladies cardio-vasculaires, chez les mammifères, y compris l'homme. Formule (I).
Pfizer Products Inc.
Sim & Mcburney
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