C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 319/08 (2006.01) A61K 31/335 (2006.01) A61K 31/665 (2006.01) A61P 27/00 (2006.01) C07C 43/23 (2006.01) C07C 59/64 (2006.01) C07C 69/16 (2006.01) C07C 69/734 (2006.01) C07C 235/32 (2006.01) C07C 311/51 (2006.01) C07D 317/50 (2006.01) C07D 317/54 (2006.01) C07D 317/60 (2006.01) C07D 407/06 (2006.01) C07F 9/655 (2006.01)
Patent
CA 2160712
Compounds of formula (I), when W is (CH2)n where n is 1 or 2, or n is 0 and W represents lower alkyl groups attached to each oxygen; m is an integer between 1 and 8; R1 is COOH or a pharmaceutically acceptable salt thereof, COOR4, CONR5R6, CONR5SO2R7, CH2OH, CH2OR7, CH2O-COR7, CH2O-CONR5,R7, CH2OCOOR7, CH2NH2, CH2NR5R6, CH2NR5COR7, CHO, CH(OR8)2, CHOR9O, - COR10, CR10(OR8)2, or CR10OR9O, where R4 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R4 is phenyl or lower alkylphenyl, R5 and R6 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or phenyl or lower alkylphenyl, R7 is alkyl of 1 to 10 carbons, phenyl or lower alkylphenyl, R8 is lower alkyl, and R9 is divalent alkyl radical of 2 - 5 carbons, R10 is an alkyl OR cycloalkyl containing 1 to 5 carbons; R2 is H, COR7, R7, CO-OR7, CO-NR5,R7, PO(OH)OR7, PO(OR7)2, POR7OH, or POR7(OR7); R3 is lower alkyl, phenyl, lower alkyl or halogen substituted phenyl, phenyl substituted lower alkyl, or heteroaryl substituted lower alkyl, are capable of lowering introaocular pressure in the eye of a mammal.
Burk Robert M.
Woodward David F.
Allergan Inc.
Gowling Lafleur Henderson Llp
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