C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/83 (2006.01) C12N 1/21 (2006.01) C12N 15/33 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2547511
The present invention provides an improved process for the production of recombinant peptides by fusion of recombinant peptides with icosahedral viral capsids and expression of the fusion in bacterial cells of Pseudomonad origin. The Pseudomonad cells support formation of virus like particles from icosahedral viral capsids in vivo, and allow the inclusion of larger recombinant peptides as monomers or concatamers in the virus like particle. The invention specifically provides cells expressing viral capsid fusions, nucleic acids encoding fusions of toxic proteins with icosahedral viral capsids and processes for manufacture of recombinant proteins.
L'invention concerne un procédé amélioré de production de peptides recombinés par fusion de peptides recombinés avec des capsides virales icosaédriques et l'expression de la fusion chez les cellules bactériennes d'origine Pseudomonade. Les cellules de Pseudomonades supportent la formation de particules du type virus à partir de capsides virales icosaédriques in vivo et permettent l'inclusion de peptides recombinés plus grands en tant que monomères ou que concatémères dans la particule du type virus. D'une manière plus spécifique, l'invention concerne des cellules exprimant des fusions de capsides virales, des fusions de codage d'acide nucléique de protéines toxiques avec des capsides virales icosaédriques et des procédés de fabrication de protéines recombinées.
Dao Philip Phuoc
Rasochova Lada
Dow Global Technolgies Inc.
Pfenex Inc.
Sim & Mcburney
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