Statistical deconvoluting of mixtures

G - Physics – 06 – F

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G06F 17/30 (2006.01) G06F 17/50 (2006.01)

Patent

CA 2286549

Statistical classification of activities of molecules is a computer implemented methodology of QSAR employing visualization of molecular features and statistical techniques for correlating features of molecules with their observed biological properties. Each molecule is described by noting the presence (1) or absence (0) of a feature of interest. The identification of specific features coded by 1's or 0's is accomplished by recursive partitioning. The data sets are planned or unplanned. The method is also applicable to classification of individuals in biological populations on the basis of their genetic makeup.

La classification statistique des activités de molécules est une méthode fondée sur la relation structure-activité (QSAR) et mise en oeuvre sur ordinateur, qui utilise la visualisation des caractéristiques moléculaires ainsi que des techniques statistiques pour corréler les caractéristiques des molécules et leurs propriétés biologiques observées. Chaque molécule est caractérisée par une valeur correspondant à la présence (1) ou l'absence (0) d'une caractéristique d'intérêt. On parvient à identifier les caractéristiques spécifiques codées par des 1 ou des 0 au moyen d'un découpage récursif. Les ensembles de données sont organisés ou non organisés. Ce procédé s'applique à la classification des individus de populations biologiques sur la base de leur constitution génétique.

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