C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01)
Patent
CA 2560539
Disclosed is an immunogenic hybrid polypeptide comprising a mimetic peptide of a B cell epitope of apolipoprotein B-100 and a helper T cell epitope, the mimetic peptide being fused at its C-terminus to an N-terminus of the helper T cell epitope. Also disclosed is a vaccine composition for preventing or treating obesity comprising the polypeptide.
La présente invention a trait à un polypeptide hybride immunogène comportant un peptide mimétique d'un site antigénique de cellule B de l'alipoprotéine B-100 et un site antigénique de lymphocyte auxiliaire, le peptide mimétique étant fusionné à son terminal C à un terminal N du site antigénique du lymphocyte T auxiliaire. L'invention a également trait à une composition vaccinale pour la prévention ou le traitement de l'obésité comportant le polypeptide.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sj Biomed Inc.
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