C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2345287
The invention provides modified proteins and DNAs of the TGF-.beta. superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through manipulation of exchange of subdomains among two or more members of the superfamily such that certain desired attributes are mixed-and-matched and then exploited therapeutically.
La présente invention concerne des ADN et des protéines modifiées de la superfamille du TGF-.beta., notamment des protéines morphogéniques modifiées. Les protéines de cette invention présentent des attributs biologiques ou biochimiques modifiés. Plus particulièrement, ces protéines modifiées sont élaborées par la manipulation ou l'échange de sous-domaines parmi deux ou plusieurs membres de la superfamille, de manière à mélanger et apparier certains attributs désirés pour les exploiter ensuite dans le domaine thérapeutique.
Mccartney John
Oppermann Hermann
Tai Mei-Sheng
Smart & Biggar
Stryker Corporation
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