C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/14 (2006.01) C12P 13/04 (2006.01) C12P 13/20 (2006.01)
Patent
CA 2264278
The regioselective and chemoselective hydrolysis of an .alpha.-ester group of an amino acid diester using pig liver esterase enzyme (PLE) is disclosed. The amino acid diesters may be either N-protected or unprotected and the diester groups may be the same or different. In particular, the preparation of a number of .gamma.-ester glutamates and .beta.-ester aspartates are provided.
Selon l'invention, on effectue une hydrolyse régiosélective et chimiosélective d'un groupe .alpha.-ester d'un diester d'acide aminé, à l'aide d'une estérase de foie de porc. Les diesters d'acides aminés peuvent être soit N-protégés, soit non protégés, et les groupes diesters peuvent être semblables ou différents. On décrit notamment la préparation d'un certain nombre de .gamma.-ester glutamates et de .beta.-esters aspartates.
Ager David J.
Pantaleone David P.
Prakash Indra
Ager David J.
Mcfadden Fincham
Nsc Technologies Llc
Pantaleone David P.
Prakash Indra
LandOfFree
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