C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01) G01N 33/554 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2069501
A monoclonal antibody which binds preferentially to a subset of the human CD4+ lymphocyte population whereby to positively and precisely distinguish between helper-inducer and supressor-inducer cells in the CD4+ cell population. The monoclonal antibody recognizes a novel antigen on the CD4+ lymphocytes by means of which it can bind CD4+ cells which express the antigen on the surface of CD4+ cells. The CD4+ subset cell population to which this antibody preferentially binds is the CD4+ helper-inducer population. This selectivity of the monoclonal antibody enables cell sorting, diagnostic and possible therapeutic applications thereof to be realized. The monoclonal antibody also reacts with CD8 cells, B cells and macrophages.
Un anticorps monoclonal qui se lie de préférence à une sous-population de la population de lymphocytes CD4+ humains qui permet de distinguer de façon positive et précise les cellules inductrices et les cellules suppressives de la population de cellules CD4+. L'anticorps monoclonal reconnaît un nouvel antigène sur les lymphocytes CD4+ par lequel il peut se lier aux cellules CD4+ qui expriment l'antigène présent à leur surface. La population de la sous-population de cellules CD4+ à laquelle se lie de préférence cet anticorps est la population de cellules CD4+ inductrices. La sélectivité de l'anticorps monoclonal permet le triage des cellules, le diagnostic et des applications thérapeutiques possibles. L'anticorps monoclonal réagit aussi avec les cellules CD8, les cellules B et les macrophages.
Morimoto Chikao
Schlossman Stuart F.
Borden Ladner Gervais Llp
Dana-Farber Cancer Institute
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