A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/506 (2006.01) A61K 31/426 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2523852
The present invention relates to a method for treating cerebral ischemia, comprising administering a compound capable of depleting mast cells or a compound inhibiting mast cells degranulation to a human in need of such treatment. Such compounds can be chosen from tyrosine kinase inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3. Preferred compounds are 2-(3-amino)arylamino-4- aryl-thiazoles or 4-(4-methylpiperazine-l-ylmethyl)-N-[4-methyl-3-(4-pyridine- 3-yl)pyrimidine-2~ylamino)phenyl]benzamide(imatinib).
L'invention concerne une méthode de traitement de l'ischémie cérébrale, consistant à administrer un composé pouvant réduire le nombre de mastocytes ou un composé à même d'inhiber la dégranulation des mastocytes chez un humain nécessitant un tel traitement. Ces composés peuvent être choisis parmi des inhibiteurs de tyrosine kinase et plus particulièrement parmi des inhibiteurs c-kit puissants, sélectifs et non toxiques. Cet inhibiteur est, de préférence, incapable de favoriser la mort de cellules dépendantes d'IL-3 cultivées en présence d'IL-3.
Kinet Jean-Pierre
Moussy Alain
Ab Science
Smart & Biggar
LandOfFree
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