C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/15 (2006.01) A61K 31/16 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 233/09 (2006.01) C07D 211/36 (2006.01) C07D 211/44 (2006.01) C07D 211/58 (2006.01) C07D 211/72 (2006.01) C07D 211/74 (2006.01) C07D 221/20 (2006.01) C07D 295/125 (2006.01) C07D 295/185 (2006.01) C07D 295/215 (2006.01) C07D 401/12 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01)
Patent
CA 2145206
Amides of formula (I), wherein: R1 is A and R2 is B; R1 is B and R2 is A; or R1 and R2 are independently selected from the group B;A is phenyl, substituted phenyl, heteroaryl, or substituted heteroaryl; B is cycloalkyl, substituted cycloalkyl, he- terocycloalkyl, or substituted heterocycloalkyl; R3 is an alkyl chain of 1 to 25 carbon atoms, branched or straight; an alkenyl chain of 2 to 25 carbon atoms, branched or straight; a substituted alkyl chain; a substituted alkenyl chain; an interrupted alkyl chain; an interrupted alkenyl chain; a substituted interrupted alkyl chain; or a substituted interrupted alkenyl chain; R4 is hydrogen, lower alkyl, phenyl, Q-substituted phenyl, heteroaryl or Q-substituted heteroaryl; R6 and R7 are both H, or R6 and R7 together represent =O; or a pharmaceutically acceptable salt thereof; useful as inhibitors of acyl-coenzyme A:cholesterol acyl transferase and therefore in the treatment of atherosclerosis are disclosed.
Schering Corporation
Swabey Ogilvy Renault
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