Novel abcg4 transporter and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2439456

The invention provides isolated nucleic acid molecules, designated ABCG4 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCG4 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which an ABCG4 transporter gene has been introduced or disrupted. The invention further provides isolated ABCG4 transporter proteins, fusion proteins, antigenic peptides, anti-ABCG4 transporter antibodies, and screening assays for ABCG4 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules d'acide nucléique isolées, appelées molécules transporteuses d'acide nucléique ABCG4, qui codent pour de nouveaux membres de la famille des transporteurs ABC. La présente invention porte également sur des molécules d'acide nucléique antisens, sur des vecteurs d'expression recombinants contenant les molécules transporteuses d'acide nucléique ABCG4, sur des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et sur des animaux transgéniques non humains dans lesquels un gène transporteur ABCG4 a été introduit ou détruit. Enfin, l'invention concerne également des protéines transporteuses ABCG4 isolées, des protéines de fusion, des peptides antigéniques, des anticorps transporteurs anti-ABCG4, des essais de criblage de modulateurs transporteurs ABCG4, ainsi que des méthodes de diagnostic et de thérapie faisant appel aux compositions de ladite invention.

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