C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/02 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 9/00 (2006.01) C12N 9/64 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2393002
The present invention relates to novel kidney related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "kikdney antigens", and the use of such kidney antigens for detecting disorders of the kidney, particularly the presence of kidney cancer and kidney cancer metastases. More specifically, isolated kidney associated nucleic acid molecules are provided encoding novel kidney associated polypeptides. Novel kidney polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human kidney associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the kidney, including kidney cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
La présente invention concerne des polynucléotides associés au rein et des polypeptides codant pour ces polynucléotides, appelés collectivement ici <= antigènes du rein >=, ainsi que l'utilisationdesdits antigènes pour la détection d'affections du rein, en particulier d'un cancer du rein, métastasé ou non. Plus précisément, l'invention concerne des molécules d'acide nucléique isolées associées au rein qui codent pour les nouveaux polypeptides associés à la glande prostatique, ainsi que des polypeptides et anticorps du rein qui se lient à ces polypeptides. L'invention concerne également des vecteurs, des cellules hôtes et des méthodes synthétiques et recombinantes permettant de produire des polynucléotides et/ou des polypeptides associés au rein humain. Par ailleurs, l'invention concerne des méthodes diagnostiques et thérapeutiques utiles pour le diagnostic, le traitement, la prévention e/ou le pronostic de troubles du rein, dont le cancer, ainsi que des méthodes de traitement de tels troubles. Sont également décrites des méthodes de criblage permettant d'identifier des agonistes et des antagonistes des polynucléotides et polypeptides de l'invention, ainsi que des méthodes et/ou des compositions propres à inhiber la production et la fonction des polypeptides selon l'invention.
Barash Steven C.
Rosen Craig A.
Ruben Steven M.
Barash Steven C.
Human Genome Sciences Inc.
Mbm & Co.
Rosen Craig A.
Ruben Steven M.
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