Antithrombotic diamides

Details Antithrombotic diamides Antithrombotic diamides

C - Chemistry, Metallurgy

07

K

C07K 5/065 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) A61K 38/05 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07K 1/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2200163

This invention relates to a compound of the Formula I X-C(O)-Y-C(O)-NH-CH2-G-Im I (wherein X, Y, G and Im have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.

Composé de formule (I) X-C(O)-Y-C(O)-NH-CH2-G-Im I (où X, Y, G et Im ont les valeurs spécifiées dans la description), ou un sel de ce composé, acceptable en pharmacie; méthodes et produits intermédiaires pour la préparation de ce composé ou de son sel; compositions pharmaceutiques renfermant ce composé ou son sel; méthodes pour les utiliser comme inhibiteurs de la thrombine, inhibiteurs de la coagulation, et agents pour le traitement des troubles thromboemboliques.

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