Aryl oxime derivatives as phosphodiesterase iv inhibitors...

Details Aryl oxime derivatives as phosphodiesterase iv inhibitors... Aryl oxime derivatives as phosphodiesterase iv inhibitors...

C - Chemistry, Metallurgy

07

D

C07D 237/04 (2006.01) A61K 31/50 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2488934

The invention relates to aryloximes of formula (I), wherein R1, R2, R3, X and B have the meanings as cited in Claim No. 1. These aryloximes act as phosphodiesterase IV inhibitors and can be used for treating osteoporosis, tumors, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.

L'invention concerne des dérivés d'aryloxymes de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, X et B ont les significations mentionnées dans la revendication 1, qui font office d'inhibiteurs de phosphodiestérase IV et s'utilisent pour traiter l'ostéoporose, des tumeurs, la cachexie, l'athérosclérose, l'arthrite rhumatoïde, la sclérose en plaques, le diabète sucré, des processus inflammatoires, des allergies, l'asthme, des maladies auto-immunes, des maladies cardiaques et le SIDA.

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