Nitroxides as protectors against oxidative stress

Details Nitroxides as protectors against oxidative stress Nitroxides as protectors against oxidative stress

A - Human Necessities

61

K

A61K 31/42 (2006.01) A61K 31/445 (2006.01) A61N 1/00 (2006.01)

Patent

CA 2078287

The instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal independent nitroxide compound which is preferably represented by formula (I), wherein R1 is -CH3; R2 is -C2H5, -C3H7, -C4H9, -C5H11, -C6H13, -CH2-CH(CH3)2, -CHCH3C2H5, or -(CH2)7-CH3, or wherein R1 and R2 together form spirocyclop- entane, spirocyclohexane, spirocycloheptane, spirocyclooctane, 5-cholestane, or norbornane, R3 is -O or -OH, or a physio- logically acceptable salt thereof, and a pharmaceutically acceptable carrier, as antioxidants capable of protecting cells, tis- sues, organs, and whole organisms against the deleterious effects of harmful oxygen-derived species generated during oxidative stress.

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