Thiazole and pyrazole derivatives as flt-3 kinase inhibitors

Details Thiazole and pyrazole derivatives as flt-3 kinase inhibitors Thiazole and pyrazole derivatives as flt-3 kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 277/42 (2006.01) A61K 31/4155 (2006.01) A61K 31/427 (2006.01) C07D 231/38 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2545350

The invention relates to thiazole and pyrazole derivatives of formula (I) wherein Q is S and X is C, or Q is CH and X is N; R1 is unsubtituted or substituted phenyl; and R2 is unsubstituted or substituted aryl or heteroaryl; oa a salt of the said compounds, and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour disease, in particular such diseases which respond to an inhibition of the FIt-3 kinase.

La présente invention a trait à des dérivés de thiazole et de pyrazole de formule (I), dans laquelle : Q est S et X est C, ou Q est CH et X est N ; R¿1? est phényle substitué ou non substitué ; et R¿2? est aryle ou hétéroaryle substitué ou non substitué ; ou un sel desdits composés et à leurs procédés de préparation, à des compositions pharmaceutiques comportant de tels dérivés et à l'utilisation de tels dérivés pour la préparation de compositions pharmaceutiques en particulier pour le traitement d'une maladie proliférante, telle qu'une maladie tumorale, notamment des maladies qui réagissent à une inhibition de la kinase Flt 3.

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