Use of a mutated macrolide binding protein for the...

Details Use of a mutated macrolide binding protein for the... Use of a mutated macrolide binding protein for the...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/13 (2006.01) C07K 7/64 (2006.01) C07K 14/715 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 9/16 (2006.01) C12N 9/90 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2263951

This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating host versus graft disease following blood marrow transplantation by transfecting stem cells so that after introduction into a patient the stem cells will express the modified cyclophilin, and, as necessary, administer the modified cyclosporin A to the patient.

Cette invention se rapporte à une cyclosporine A modifiée et à une version modifiée par génie génétique de son récepteur, la cyclophiline. Cette invention se rapporte en outre à un procédé pour traiter la réaction du greffon contre l'hôte après une greffe de moelle osseuse par transfection de cellules souches, pour que, après introduction dans le corps d'un patient, les cellules souches expriment la cyclophiline modifiée et, si nécessaire, administrent la cyclosporine A modifiée dans le corps du patient.

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