Hsv strain lacking functional icp27 and icp34.5 genes

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 7/01 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/035 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2262010

The present invention provides a herpes simplex virus strain which lacks a functional ICP34.5 gene and a functional ICP27 gene. It also provides the use of a herpes simplex virus strain which lacks a functional ICP34.5 gene and a functional ICP27 gene in the treatment of disorders of, or injuries to, the nervous system of a mammal.

La présente invention concerne une souche du virus de l'herpès simplex à laquelle il manque un gène ICP34.5 fonctionnel et un gène ICP27 fonctionnel. L'invention concerne également l'utilisation, chez les mammifères, d'une souche du virus de l'herpès simplex à laquelle il manque un gène ICP34.5 fonctionnel et un gène ICP27 fonctionnel pour le traitement de troubles ou lésions du système nerveux.

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