C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/30 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/18 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2202912
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
L'invention porte sur de nouveaux ligands protéiques au domaine de mort du récepteur du facteur de nécrose tumorale TNF ("TNF-R1-DD"), sur des polynucléotides codant lesdits ligands protéiques du TNF-R1-DD, sur des vecteurs, sur des cellules hôtes et sur des procédés d'obtention dudit ligand protéique du TNF-R1-DD. L'invention porte également sur des préparations pharmaceutiques contenant ledit ligand protéique, sur des méthodes de traitement d'états inflammatoires et d'inhibition de la fixation au domaine de mort du TNF-R, ainsi que sur des méthodes d'identification d'inhibiteurs de fixation au domaine de mort du TNF-R, et sur les inhibiteurs ainsi identifiés.
Chen Jennifer
Graham James
Lin Lih-Ling
Schievella Andrea R.
Genetics Institute Inc.
Genetics Institute Llc
Torys Llp
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