Methods for selection of recombinant host cells expressing...

Details Methods for selection of recombinant host cells expressing... Methods for selection of recombinant host cells expressing...

C - Chemistry, Metallurgy

12

N

C12N 15/64 (2006.01) C07K 14/61 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2104598

The present invention relates to improved methods for the selection of recombinant host cells expressing high levels of a desired protein, which methods are useful with a wide variety of eukaryotic host cells and avoid the problems inherent in existing cell selection technology. The invention further relates to intron-modified selectable genes, comprising the coding sequence of a selectable gene and an intron that reduces the level of selectable protein produced from the selectable gene in a host cell, which are useful in the methods of the invention.

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