C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2316269
The invention concerns peptides comprising epitopes recognised by antifilaggrin in serum from rheumatoid arthritis patients. Said epitopes comprising a tripeptide motif centred on a citrulline residue. The invention also concerns artificial antigens comprising said epitopes, and their use for diagnosing rheumatoid arthritis.
L'invention est relative à des peptides comprenant des épitopes reconnus par des auto-anticorps antifilaggrine présents dans le sérum des patients atteints de polyarthrite rhumatoïde. Lesdits épitopes comprennent un motif tripeptidique centré sur un résidu citrulline. L'invention est également relative à des antigènes artificiels comprenant ces épitopes, et à leur utilisation de cet antigène pour le diagnostic de la polyarthrite rhumatoïde.
Arnaud Michel
Dalbon Pascal
Girbal-Neuhauser Elisabeth
Jolivet Michel
Jolivet-Reynaud Colette
Biomerieux
Robic
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