Fibronectin polypeptides and methods of use

A - Human Necessities – 61 – K

Patent

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A61K 48/00 (2006.01)

Patent

CA 2624900

Described herein are fragments of fibronectin and variants thereof that bind growth factors. Compositions containing such a fragment of fibronectin are therefore useful in sequestering growth factors, and complexes containing both a FN fragment and a bound, active growth factor can be used to deliver growth factors to a patient (e.g., to a wound on the patient's skin).

cette invention concerne des fragments de fibronectine et des variants qui se lient à des facteurs de croissance. Il en résulte que des compositions contenant un tel fragment de fibronectine sont utiles pour séquestrer des facteurs de croissance. Des complexes contenant à la fois un fragment de fibronectine et un facteur de croissance actif lié peuvent être utilisés pour l'administration de facteurs de croissance à un patient (par exemple sur une lésion de la peau).

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