Polypeptid connected with an organic residue

Details Polypeptid connected with an organic residue Polypeptid connected with an organic residue

C - Chemistry, Metallurgy

07

K

C07K 1/107 (2006.01)

Patent

CA 2572245

The invention relates to a method for producing a polypeptide which is modified with an organic group, wherein a bioactive polypeptide is covalently bound to an organic group that comprises a backbone structure having aromatic side chains, thereby forming a modified polypeptide which is constituted of the bioactive polypeptide and the group having aromatic side chains. At least one of the aromatic side chains of the group is subjected to chemical or enzymatic hydroxylation.

L'invention concerne un procédé pour produire un polypeptide modifié avec un groupe organique, procédé selon lequel un polypeptide bioactif est lié par covalence à un groupe organique, qui présente une structure de squelette à chaînes latérales aromatiques, et un polypeptide modifié est formé à partir du polypeptide bioactif et du groupe à chaînes latérales aromatiques, au moins une chaîne latérale aromatique de ce groupe étant hydroxylée chimiquement ou enzymatiquement.

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