C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) C07K 14/515 (2006.01)
Patent
CA 2485587
The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.
L'invention concerne des mutéines de facteur de croissance placentaire de type 1 (PLGF-1) chimiquement stables impliquant la substitution ou l'élimination d'un résidu de cystéine provenant d'une séquence d'acide aminé protéique de type sauvage; leur préparation; leurs utilisations thérapeutiques et cosmétiques; et des compositions pharmaceutiques et cosmétiques contenant lesdits dérivés. L'invention concerne également la production d'anticorps contre ces dérivés et leur utilisation pour diagnostiquer et traiter des pathologies tumorales et non tumorales.
Battisti Mauro
Conti Ettore
Maglione Domenico
Mion Alberto
Salvia Giuseppe
Fetherstonhaugh & Co.
Geymonat S.p.a.
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