Indol-3-yl derivatives

Details Indol-3-yl derivatives Indol-3-yl derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 209/18 (2006.01) C07D 403/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2399813

Indol-3-yl derivatives of the general formula I (see formula I) in which A, B, X, R1, R2, R3, R4, R5, n and m are as defined in Patent Claim 1, and their physiologically acceptable salts or solvates are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart diseases, arteriosclerosis, inflammations, tumours, osteoporosis, rheumatic arthritis, macular degenerative disease, diabetic retinopathy, infections and restenosis after angioplasty or in pathological processes maintained or propagated by angiogenesis.

L'invention concerne des dérivés d'indol-3-yl de la formule générale (I) où A, B, X, R<1>, R<2>, R<3>, R<4>, R<5>, n ou m ont la signification indiquée dans la revendication 1, et leurs sels et solvates physiologiquement acceptables. Ce sont des inhibiteurs d'intégrine et ils s'avèrent utiles dans la lutte contre les thromboses, l'infarctus du myocarde, les coronaropathies, l'artériosclérose, les inflammations, les tumeurs, l'ostéoporose, la polyarthrite rhumatoïde, la dégénérescence maculaire, la rétinopathie diabétique, les infections et la resténose après angioplastie, ou lors de processus pathologiques entretenus et propagés par l'angiogénèse.

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