C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/7088 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2742596
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR2. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR2. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR2 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR2 expression and for prevention or treatment of diseases wherein modulation of TLR2 expression would be beneficial are provided.
L'invention porte sur des composés oligonucléotidiques antisens, des compositions et des procédés permettant une régulation négative de l'expression de TLR2. Les compositions contiennent des oligonucléotides antisens ciblés vers des acides nucléiques codant pour TLR2. Les compositions peuvent également contenir des oligonucléotides antisens ciblés vers des acides nucléiques codant pour TLR2 en combinaison avec d'autres composés et/ou compositions thérapeutiques et/ou prophylactiques. L'invention porte sur des procédés d'utilisation de ces composés et de ces compositions en vue dune régulation négative de l'expression de TLR2 et de la prévention ou du traitement de maladies dans lesquelles la modulation de l'expression de TLR2 serait bénéfique.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar
Putta Mallikarjuna
Wang Daqing
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Idera Pharmaceuticals Inc.
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