Peptide mimetics

Details Peptide mimetics Peptide mimetics

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A01K 67/00 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 14/61 (2006.01) C07K 16/24 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2418913

The invention relates to peptide mimetics of cytokine molecules that comprise an atypical helix-turn-helix motif that has been mutated to incorporate one or more amino acid residues from the active site of said cytokine molecule. In particular, the invention relates to peptide mimetics of type I cytokine molecules such as interleukin 4, (IL-4), human growth hormone (HGH) and interleukin 2 (IL-2).

L'invention concerne des mimétismes de peptides de molécules de cytokine contenant un motif atypique hélice-coude-hélice ayant subi une mutation de manière à intégrer un ou plusieurs résidus d'acides aminés à partir du site actif de ladite molécule de cytokine. Ladite invention concerne en particulier des mimétismes de peptides de molécules de cytokine de type I telles que l'interleukine 4 (IL-4), les hormones de croissance humaine (HCH), et l'interleukine 2 (IL-2).

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