C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/0735 (2010.01) C12N 5/077 (2010.01) A61K 35/34 (2006.01) A61P 9/00 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2453438
This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell surface and morphologic markers characteristic of cardiomyocytes, and a proportion of them undergo spontaneous periodic contraction. Highly enriched populations of cardiomyocytes and their replicating precursors can be obtained, suitable for use in a variety of applications, such as drug screening and therapy for cardiac disease.
L'invention concerne des populations de cellules humaines de la lignée des cardiomyocytes. On obtient ces cellules par provocation de la différentiation in vitro de culture de cellules souches pluripotentielles, puis par extraction des cellules présentant certaines caractéristiques phénotypiques. Certaines cellules différenciées portent des marqueurs morphologiques et des marqueurs de surface caractéristiques des cardiomyocytes et une proportion de ces cellules est soumise à une contraction périodique spontanée. Ceci permet d'obtenir des populations de cardiomyocytes extrêmement enrichies, ainsi que leurs précurseurs de réplication, et de mettre ces derniers en application dans une variété de domaines, tels que le criblage de médicaments et le traitement de maladies cardiaques.
Geron Corporation
Smart & Biggar
LandOfFree
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