Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and...

Details Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and... Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/41 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2082500

ABSTRACT OF THE DISCLOSURE Image (I) This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or (CH2)m R3 where R3 is cycoalkyl and m is 1 or 2; R1 is alkyl; R2 is hydrogen or alkyl; R4 is alkyl; n is an interger from 1 to 5; p is an interger from 0 to 6; Y is NH, oxygen or sulfur; and Z is hydrogen, alkyl, alkoxy, NR4R5 wherein R4 and R5 are independently hydrogen or alkyl, or SR6 wherein R6 is hydrogen, benzyl or alkyl. The compounds of formula (I) are leukotriene B4 antagonists and are useful as anti-inflammatory agents and in the treatment of leukotriene B4 mediated conditions.

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