Recombinant protein carrying human papillomavirus epitopes...

Details Recombinant protein carrying human papillomavirus epitopes... Recombinant protein carrying human papillomavirus epitopes...

A - Human Necessities

61

K

A61K 39/12 (2006.01) C07K 14/025 (2006.01) C07K 14/235 (2006.01) C12N 9/88 (2006.01)

Patent

CA 2559235

The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding thesame. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.

L'invention concerne une protéine recombinée qui comprend un ou plusieurs polypeptides portant un ou plusieurs épitopes d'un ou de plusieurs antigènes du VPH, lesdits polypeptides étant insérés dans des sites permissifs identiques ou différents d'une protéine d'adénylate cyclase (CyaA) ou d'un fragment de celle-ci. Ledit fragment de CyaA conserve la propriété de la protéine d'adénylate cyclase de cibler les cellules présentatrices d'antigène. L'invention concerne aussi des polynucléotides codant pour cette protéine. La protéine recombinée ou le polynucléotide peuvent servir à mettre au point des moyens thérapeutiques dirigés contre l'infection à VPH ou ses effets malins.

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