Methods for production of proteins in host cells

Details Methods for production of proteins in host cells Methods for production of proteins in host cells

C - Chemistry, Metallurgy

12

N

C12N 15/70 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2385766

The present invention provides methods for the production of proteins, particularly toxic proteins, in host cells. The invention provides methods which use a fusion protein comprising a chaperonin binding domain in host cells induced or regulated to have increased levels of chaperonin which binds the chaperonin binding domain.

La présente invention concerne des méthodes de production de protéines, en particulier de protéines toxiques, dans des cellules hôtes. L'invention concerne des méthodes dans lesquelles on utilise une protéine de fusion comprenant un domaine de fixation de chaperonine dans des cellules hôtes induites ou régulées de façon à posséder des niveaux plus élevés de chaperonine se fixant au domaine de fixation de chaperonine.

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