Use of agt and its derivatives for manufacturing...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 17/06 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2445298

An object of the present invention is the use of at least one inhibitor of angiogenesis consisting of AGT or derivatives thereof in the manufacture of a drug for treating pathologies or disorders notably angiogenesis-dependent or mediated pathologies generally characterised by excessive angiogenesis.The present invention also relates to a cell transfected with at least one expression vector wherein said expression vector hosts a recombinant nucleic acid encoding an AGT or one of its derivatives for use in therapy of angiogenesis-mediated pathologies. The present invention further relates to an expression vector for use in said cell.

Un aspect de la présente invention concerne l'utilisation d'au moins un inhibiteur de l'angiogenèse constitué d'angiotensinogène (AGT) ou de ses dérivés dans la préparation d'un médicament utile pour traiter les pathologies ou les troubles, notamment les pathologies induites par l'angiogenèse ou dépendant de cette dernière qui sont en général caractérisées par une angiogenèse excessive. Un deuxième aspect de cette invention concerne une cellule transfectée par au moins un vecteur d'expression dans laquelle le vecteur d'expression héberge un acide nucléique de recombinaison codant un AGT ou un de ses dérivés qu'on utilise en thérapie pour les pathologies induites par l'angiogenèse. Cette invention concerne également un vecteur d'expression destiné à être utilisé dans ladite cellule.

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